microtubule inhibitor 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61749	Microtubule inhibitor 2
	Microtubule inhibitor 2 is a highly potent and selective microtubule inhibitor, which is orally active. It induces cell death via ferroptosis, and exhibits notable antitumor activity [1].
T60026	KIF18A-IN-2		Microtubule Associated
	KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.		Microtubule Associated
T50005	Sertaconazole		Antifungal
	Sertaconazole is a broad-spectrum antifungal.		Antifungal
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T13298	Verubulin hydrochloride	MPC-6827 hydrochloride	Microtubule Associated
	Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anticancer activity in human MX-1 brea...		Microtubule Associated
T15576	Indibulin	ZIO 301,D 24851	Apoptosis , Microtubule Associated
	Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu...		Apoptosis , Microtubule Associated
T6665	Sertaconazole nitrate	FI-7045,Ginedermofix,FI7056,Ertaczo	Antibiotic , Antifungal
	Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections.		Antibiotic , Antifungal
T35548	Dynapyrazole A		Dynamin
	Dynapyrazole A is a specific inhibitor of microtubule dynamin with IC50s of 2.3 and 2.6 μM for dynein 1 and dynein 2-dependent microtubule gliding. Dynapyrazole A inhibits Hedgehog signaling with an IC50 of 1.9 μM.		Dynamin
T15612	JH-VIII-157-02		Microtubule Associated , ALK
	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L...		Microtubule Associated , ALK
T1034	Docetaxel	NSC 628503,RP-56976	Apoptosis , Microtubule Associated , Endogenous Metabolite
	Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,...		Apoptosis , Microtubule Associated , Endogenous Metabolite
T15183	Dynarrestin		Hedgehog/Smoothened
	Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. It inhibits dynein 1-driven microtubule gliding in vitro pl...		Hedgehog/Smoothened
T62642	Microtubule inhibitor 4
	Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity.
T11946	MARK-IN-2		Others
	MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).		Others
T18871	VCP-Eribulin		Others
	VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].		Others
T81850	MASTL-IN-2
	MASTL-IN-2 is a potent inhibitor of microtubule-associated serine/threonine kinase-like (MASTL). It demonstrates notable efficacy in suppressing the proliferation of human epithelial MIA PaCa cancer cells, exhibiting an ...
T37037	Vinflunine ditartrate
	Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for study...
T74761	Eleutherobin
	Eleutherobin, a potent β-microtubule inhibitor with an IC50 value of 2 μM, exhibits cytotoxic activity against cancer cells at a potency comparable to Paclitaxel. This compound is derived from marine soft coral and is kn...
T75521	PM050489
	PM050489, a potent polyketone inhibitor of Microtubule/Tubulin isolated from the Madagascan sponge Lithoplocamia lithistoides, effectively inhibits mitosis with an IC 50 value of 26.4 nM. This compound exhibits antitumor...
T79232	MARK4 inhibitor 2		AMPK
	MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM. It effectively inhibits the growth of human cells, thereby offering potentia...		AMPK
T68401	IG-105
	IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has go...